How To Clean Night Guard With Baking Soda. To keep your mouth guard case clean, wash it every few days with normal dish soap (preferably fragrance free). Use a separate soft bristled toothbrush just for cleaning your night guard.
The best way to clean a night guard is to brush it with your toothbrush gently after rinsing. After soaking, rinse the night guard and the bowl with water. Rinse your mouth guard or night guard under lukewarm tap water.
Dentists recommend that you skip the toothpaste entirely.
This will keep your oral appliance disinfected and clean. Any experience you can share is most welcome ! Mix 3/4 of a cup of water with two tablespoons of baking soda. The next day, use a toothbrush to scrub the night guard.